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drp1  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc drp1
    A , gene expression of fission and fusion markers Fis1, <t>Drp1,</t> OPA1 and MFN2 in FXN‐cKO and FXNKD hearts normalized to controls. B , western blot images of the corresponding proteins involved in mitochondrial fission–fusion processes. C , protein expression of fission and fusion markers Fis1, Drp1, OPA1 and MFN2 in FXN‐cKO and FXNKD mice normalized to controls. D , protein expression of OPA1‐l/OPA1‐s ratio in FXN‐cKO hearts. E , OPA1‐l/OPA1‐s ratio in FXNKD hearts. F , schematic representation of fusion and fission. N = 8 mouse hearts per genotype for gene expression and n = 4 mouse hearts per genotype for protein expression. Numbers above the brackets indicate the exact P ‐value.
    Drp1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 97/100, based on 946 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/drp1/DRP1+Rabbit+mAb/pmc13674193-101-7-8
    Average 97 stars, based on 946 article reviews
    drp1 - by Bioz Stars, 2026-10
    97/100 stars

    Images

    1) Product Images from "Mitochondrial dynamics and repair differences in two mouse models of Friedreich's ataxia"

    Article Title: Mitochondrial dynamics and repair differences in two mouse models of Friedreich's ataxia

    Journal: The Journal of Physiology

    doi: 10.1113/JP291356

    A , gene expression of fission and fusion markers Fis1, Drp1, OPA1 and MFN2 in FXN‐cKO and FXNKD hearts normalized to controls. B , western blot images of the corresponding proteins involved in mitochondrial fission–fusion processes. C , protein expression of fission and fusion markers Fis1, Drp1, OPA1 and MFN2 in FXN‐cKO and FXNKD mice normalized to controls. D , protein expression of OPA1‐l/OPA1‐s ratio in FXN‐cKO hearts. E , OPA1‐l/OPA1‐s ratio in FXNKD hearts. F , schematic representation of fusion and fission. N = 8 mouse hearts per genotype for gene expression and n = 4 mouse hearts per genotype for protein expression. Numbers above the brackets indicate the exact P ‐value.
    Figure Legend Snippet: A , gene expression of fission and fusion markers Fis1, Drp1, OPA1 and MFN2 in FXN‐cKO and FXNKD hearts normalized to controls. B , western blot images of the corresponding proteins involved in mitochondrial fission–fusion processes. C , protein expression of fission and fusion markers Fis1, Drp1, OPA1 and MFN2 in FXN‐cKO and FXNKD mice normalized to controls. D , protein expression of OPA1‐l/OPA1‐s ratio in FXN‐cKO hearts. E , OPA1‐l/OPA1‐s ratio in FXNKD hearts. F , schematic representation of fusion and fission. N = 8 mouse hearts per genotype for gene expression and n = 4 mouse hearts per genotype for protein expression. Numbers above the brackets indicate the exact P ‐value.

    Techniques Used: Gene Expression, Western Blot, Expressing

    Related Articles

    Incubation:

    Article Title: A dual-responsive CO-releasing nanogel ameliorates retinal ischemia–reperfusion injury by restoring mitochondrial homeostasis and attenuating cGAS-STING pathway activation
    Article Snippet: .. The following primary antibodies were used: Drp1 (CST, #8570, 1:1000, ∼80 kDa), Fis1 (Proteintech, 10956-1-AP, 1:1000, ∼17 kDa), Mfn1 (Abcam, ab104274, 1:1000, ∼84 kDa), Mfn2 (CST, #9482, 1:1000, ∼86 kDa), Opa1 (CST, #80471, 1:1000, ∼100–120 kDa), Pink1 (CST, #6946, 1:1000, ∼63 kDa), cGAS (CST, #15102, 1:1000, ∼60 kDa), STING (CST, #13647, 1:1000, ∼42–45 kDa), TBK1 (CST, #3013, 1:1000, ∼84 kDa), p-TBK1 (CST, #5483, 1:1000, ∼84 kDa), COX IV (Abcam, ab14744, 1:2000, ∼17 kDa), β-actin (Proteintech, 66009-1-Ig, 1:5000, ∼43 kDa), and GAPDH (Proteintech, 60004-1-Ig, 1:5000, After washing, the membranes were incubated with HRP-conjugated secondary antibodies (goat anti-rabbit or goat anti-mouse IgG, CST, 1:5000) for 1 h at room temperature. .. The signals were visualized via an enhanced chemiluminescence (ECL) detection kit (Thermo Fisher Scientific) and imaged with the Bio-Rad ChemiDoc MP system.

    Article Title: ALDOB K87 lactylation drives mitochondrial fission and metabolic reprogramming in pulmonary hypertension.
    Article Snippet: .. The cells fixed with 4% paraformaldehyde were permeabilized with 0.1% Triton X-100, blocked in 5% BSA, and incubated overnight with primary antibodies against TOM20 (mitochondrial marker, 1:500, #ab186735; Abcam) and DRP1 (1:200, #8570; CST). .. Alexa Fluor 488/594-conjugated secondary antibodies (1:1000; Invitrogen) were applied for 1 h, and the nuclei were counterstained with DAPI.

    Article Title: Metabolic commitment to human motor neurons is characterized by mitochondrial depletion and pyruvate rewiring
    Article Snippet: Proteins were transferred to a Trans-Blot Turbo Mini 0.2 μm Nitrocellulose (BioRad #1704158) using the Trans-Blot Turbo transfer system (Bio-Rad). .. Membranes were blocked with 5% milk (or 3% BSA for phosphorylated proteins) in TBS-T for 1 hour at room temperature, followed by overnight incubation with primary antibodies prepared in 3% BSA in TBS-T: ATP5A (Abcam #ab14748, 1:1000), BNIP3 (Abcam, # ab109362, 1:1000), COXII (Abcam, #ab79393, 1:1000), DNAJA3 (TID1), DRP1 (CellSignaling, #5391, 1:1000), DRP1 s616 (Cell Signaling, #3455, 1:1000), DRP1 s637 (Abcam, #ab193216, 1:1000), GAPDH (Cell Signaling, # 2118, 1:1000), Histone 3 (Cell Signaling, # 4499, 1:1000), ((Abcam, #ab181024, 1:1000), HSP60 (Santa Cruz, #sc-1052, 1:200), MT-CO1 (Abcam, #ab14705, 1:1000), Nanog (Cell Signaling, #4903S, 1:2000), NDUFA9 (Abcam, #ab14713, 1:2000), NIX (Cell Signaling, #12396S, 1:1000), COX7A2L (Proteintech #11416-1-AP, 1:500), LC3B (Abcam, #ab51520, 1:1000), LDHA (Cell Signaling, #3582, 1:1000), SDHA (Abcam #ab14715, 1:2000), SDHB (Abcam #ab14714 1:1000), SOX1 (R and D Syst, #MAB3369, 1:1000), SQTM1 (p62) (Abnova, #H00008878-M01, 1:5000), PDHA1 (Abcam #ab110330, 1:2000), PDHA1 S293 (Abcam #ab177461, 1:2000), TOM20 (Santa Cruz, #sc1-17764, 1:500), TOM40 (Santa Cruz, #sc-11414, 1:1000), UQCRC2 (Abcam, #ab14745, 1:1000; Proteintech #14742-1-AP, 1:1000), VDAC1/3 (porin) (Abcam, #ab14734, 1:2000), Vinculin (Sigma, #V9264-25UL, 1:10000). ..

    Marker:

    Article Title: ALDOB K87 lactylation drives mitochondrial fission and metabolic reprogramming in pulmonary hypertension.
    Article Snippet: .. The cells fixed with 4% paraformaldehyde were permeabilized with 0.1% Triton X-100, blocked in 5% BSA, and incubated overnight with primary antibodies against TOM20 (mitochondrial marker, 1:500, #ab186735; Abcam) and DRP1 (1:200, #8570; CST). .. Alexa Fluor 488/594-conjugated secondary antibodies (1:1000; Invitrogen) were applied for 1 h, and the nuclei were counterstained with DAPI.

    Multiplex Assay:

    Article Title: Excessive ER-mitochondria coupling: A DRP1-driven mechanism underlying mitochondrial dysfunction and impaired autophagy in stress-induced depression-like behavior in mice
    Article Snippet: Brain tissues were fixed in 4% paraformaldehyde and cryopreserved in OCT compound (Thermo NEG-50). .. Multiplex staining was performed using TSA-based immunofluorescence with primary antibodies: Drp1 (CST 12741S, 1:100), MAP2 (ab32454, 1:1000), GFAP (CST 12389, 1:400), IBA1 (ab178846, 1:1000), Vglut1 (CST #27181, 1:800), Vglut2 (ab216463, 1:250), OLIG2 (CST #65915, 1:400), and LAMP1 (CST 99437S, 1:100). ..

    Staining:

    Article Title: Excessive ER-mitochondria coupling: A DRP1-driven mechanism underlying mitochondrial dysfunction and impaired autophagy in stress-induced depression-like behavior in mice
    Article Snippet: Brain tissues were fixed in 4% paraformaldehyde and cryopreserved in OCT compound (Thermo NEG-50). .. Multiplex staining was performed using TSA-based immunofluorescence with primary antibodies: Drp1 (CST 12741S, 1:100), MAP2 (ab32454, 1:1000), GFAP (CST 12389, 1:400), IBA1 (ab178846, 1:1000), Vglut1 (CST #27181, 1:800), Vglut2 (ab216463, 1:250), OLIG2 (CST #65915, 1:400), and LAMP1 (CST 99437S, 1:100). ..

    Immunofluorescence:

    Article Title: Excessive ER-mitochondria coupling: A DRP1-driven mechanism underlying mitochondrial dysfunction and impaired autophagy in stress-induced depression-like behavior in mice
    Article Snippet: Brain tissues were fixed in 4% paraformaldehyde and cryopreserved in OCT compound (Thermo NEG-50). .. Multiplex staining was performed using TSA-based immunofluorescence with primary antibodies: Drp1 (CST 12741S, 1:100), MAP2 (ab32454, 1:1000), GFAP (CST 12389, 1:400), IBA1 (ab178846, 1:1000), Vglut1 (CST #27181, 1:800), Vglut2 (ab216463, 1:250), OLIG2 (CST #65915, 1:400), and LAMP1 (CST 99437S, 1:100). ..

    Transcranial Magnetic Stimulation:

    Article Title: Metabolic commitment to human motor neurons is characterized by mitochondrial depletion and pyruvate rewiring
    Article Snippet: Proteins were transferred to a Trans-Blot Turbo Mini 0.2 μm Nitrocellulose (BioRad #1704158) using the Trans-Blot Turbo transfer system (Bio-Rad). .. Membranes were blocked with 5% milk (or 3% BSA for phosphorylated proteins) in TBS-T for 1 hour at room temperature, followed by overnight incubation with primary antibodies prepared in 3% BSA in TBS-T: ATP5A (Abcam #ab14748, 1:1000), BNIP3 (Abcam, # ab109362, 1:1000), COXII (Abcam, #ab79393, 1:1000), DNAJA3 (TID1), DRP1 (CellSignaling, #5391, 1:1000), DRP1 s616 (Cell Signaling, #3455, 1:1000), DRP1 s637 (Abcam, #ab193216, 1:1000), GAPDH (Cell Signaling, # 2118, 1:1000), Histone 3 (Cell Signaling, # 4499, 1:1000), ((Abcam, #ab181024, 1:1000), HSP60 (Santa Cruz, #sc-1052, 1:200), MT-CO1 (Abcam, #ab14705, 1:1000), Nanog (Cell Signaling, #4903S, 1:2000), NDUFA9 (Abcam, #ab14713, 1:2000), NIX (Cell Signaling, #12396S, 1:1000), COX7A2L (Proteintech #11416-1-AP, 1:500), LC3B (Abcam, #ab51520, 1:1000), LDHA (Cell Signaling, #3582, 1:1000), SDHA (Abcam #ab14715, 1:2000), SDHB (Abcam #ab14714 1:1000), SOX1 (R and D Syst, #MAB3369, 1:1000), SQTM1 (p62) (Abnova, #H00008878-M01, 1:5000), PDHA1 (Abcam #ab110330, 1:2000), PDHA1 S293 (Abcam #ab177461, 1:2000), TOM20 (Santa Cruz, #sc1-17764, 1:500), TOM40 (Santa Cruz, #sc-11414, 1:1000), UQCRC2 (Abcam, #ab14745, 1:1000; Proteintech #14742-1-AP, 1:1000), VDAC1/3 (porin) (Abcam, #ab14734, 1:2000), Vinculin (Sigma, #V9264-25UL, 1:10000). ..

    Cell-Signaling:

    Article Title: Metabolic commitment to human motor neurons is characterized by mitochondrial depletion and pyruvate rewiring
    Article Snippet: Proteins were transferred to a Trans-Blot Turbo Mini 0.2 μm Nitrocellulose (BioRad #1704158) using the Trans-Blot Turbo transfer system (Bio-Rad). .. Membranes were blocked with 5% milk (or 3% BSA for phosphorylated proteins) in TBS-T for 1 hour at room temperature, followed by overnight incubation with primary antibodies prepared in 3% BSA in TBS-T: ATP5A (Abcam #ab14748, 1:1000), BNIP3 (Abcam, # ab109362, 1:1000), COXII (Abcam, #ab79393, 1:1000), DNAJA3 (TID1), DRP1 (CellSignaling, #5391, 1:1000), DRP1 s616 (Cell Signaling, #3455, 1:1000), DRP1 s637 (Abcam, #ab193216, 1:1000), GAPDH (Cell Signaling, # 2118, 1:1000), Histone 3 (Cell Signaling, # 4499, 1:1000), ((Abcam, #ab181024, 1:1000), HSP60 (Santa Cruz, #sc-1052, 1:200), MT-CO1 (Abcam, #ab14705, 1:1000), Nanog (Cell Signaling, #4903S, 1:2000), NDUFA9 (Abcam, #ab14713, 1:2000), NIX (Cell Signaling, #12396S, 1:1000), COX7A2L (Proteintech #11416-1-AP, 1:500), LC3B (Abcam, #ab51520, 1:1000), LDHA (Cell Signaling, #3582, 1:1000), SDHA (Abcam #ab14715, 1:2000), SDHB (Abcam #ab14714 1:1000), SOX1 (R and D Syst, #MAB3369, 1:1000), SQTM1 (p62) (Abnova, #H00008878-M01, 1:5000), PDHA1 (Abcam #ab110330, 1:2000), PDHA1 S293 (Abcam #ab177461, 1:2000), TOM20 (Santa Cruz, #sc1-17764, 1:500), TOM40 (Santa Cruz, #sc-11414, 1:1000), UQCRC2 (Abcam, #ab14745, 1:1000; Proteintech #14742-1-AP, 1:1000), VDAC1/3 (porin) (Abcam, #ab14734, 1:2000), Vinculin (Sigma, #V9264-25UL, 1:10000). ..

    other:

    Article Title: Mitochondrial dynamics and repair differences in two mouse models of Friedreich's ataxia
    Article Snippet: Primary antibodies: TFAM (Cell Signalling Technology, 8076), DRP1 (Cell Signalling Technology, 8570), FIS1 (Cell Signalling Technology, 32525), MFN2 (Abcam, ab56889), OPA1 (Cell Signalling Technology, 8047), Pink1 (Abcam, 23707), Parkin (Cell Signalling Technology, 32833), p62 (Abcam, ab56416), FUNDC1 (Cell Signalling Technology, 49240), BNIP3L (Cell Signalling Technology, 12396), LC3 (Cell Signalling Technology, 12 741), ATG7 (Cell Signalling Technology, 8558), ATG12–5 (Cell Signalling Technology, 4180), LAMP1 (Abcam, 24170), CD63 (Cell Signalling Technology, 10112), Cathepsin D (Cell Signalling, 74089), GAPDH (Abcam, ab8245), αTubulin (Millipore Sigma, T6199).



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    Cell Signaling Technology Inc phospho drp1 ser616 d9a1 rabbit monoclonal
    A , gene expression of fission and fusion markers Fis1, <t>Drp1,</t> OPA1 and MFN2 in FXN‐cKO and FXNKD hearts normalized to controls. B , western blot images of the corresponding proteins involved in mitochondrial fission–fusion processes. C , protein expression of fission and fusion markers Fis1, Drp1, OPA1 and MFN2 in FXN‐cKO and FXNKD mice normalized to controls. D , protein expression of OPA1‐l/OPA1‐s ratio in FXN‐cKO hearts. E , OPA1‐l/OPA1‐s ratio in FXNKD hearts. F , schematic representation of fusion and fission. N = 8 mouse hearts per genotype for gene expression and n = 4 mouse hearts per genotype for protein expression. Numbers above the brackets indicate the exact P ‐value.
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    USP18 aggravates cardiac I/R injury through regulation of mitochondria and inhibition of mitophagy. a Electron microscopy image showing mitophagy in USP18-cKO mouse hearts ( n= 5). Scale bar=3 μm. White arrowheads indicate sites of mitophagy. b Protein levels of PINK1, Parkin, ubiquitinated proteins (Ub), P62, and LC3II in mitochondria from heart tissue in USP18-cKO and WT mice 24 h after I/R injury ( n =4). c Electron microscopy image showing mitophagy in USP18-overexpres (OV) mouse hearts ( n =5). Scale bar=3 μm. White arrowheads indicate sites of mitophagy. d Protein levels of PINK1, Parkin, Ub, P62, and LC3II proteins in mitochondria from the heart tissue of USP18-OV mice 24 h after I/R injury ( n =4). Color shift in mitophagy dye (red) and lysosomal dye (green) in NRVMs showing mitophagy in NRVMs with USP18 siRNA transfection ( e ) or Ad-USP18 infection ( f ) and the quantitative mitophagy index in each group ( n= 5). Scale bar=9 μm. Protein levels of PINK1, Parkin, Ub, P62, and LC3II in mitochondria from NRVMs transfected with USP18 siRNA ( g ) or infected with Ad-USP18 ( h ). ⁎⁎ P <0.01, ⁎⁎⁎ P <0.001 ⁎⁎⁎⁎ P <0.0001. USP18. Ubiquitin-specific protease 18; I/R. Ischemia/reperfusion; WT. Wild-type; KO. Knockout; P62. Sequestosome 1; LC3. Microtubule-associated protein 1 light chain 3; VDAC. Voltage-dependent anion channel.

    Journal: Military Medical Research

    Article Title: USP18 exacerbates myocardial I/R injury by inhibiting Parkin mitophagy through the deubiquitinase PTEN-L

    doi: 10.1016/j.mmr.2026.100004

    Figure Lengend Snippet: USP18 aggravates cardiac I/R injury through regulation of mitochondria and inhibition of mitophagy. a Electron microscopy image showing mitophagy in USP18-cKO mouse hearts ( n= 5). Scale bar=3 μm. White arrowheads indicate sites of mitophagy. b Protein levels of PINK1, Parkin, ubiquitinated proteins (Ub), P62, and LC3II in mitochondria from heart tissue in USP18-cKO and WT mice 24 h after I/R injury ( n =4). c Electron microscopy image showing mitophagy in USP18-overexpres (OV) mouse hearts ( n =5). Scale bar=3 μm. White arrowheads indicate sites of mitophagy. d Protein levels of PINK1, Parkin, Ub, P62, and LC3II proteins in mitochondria from the heart tissue of USP18-OV mice 24 h after I/R injury ( n =4). Color shift in mitophagy dye (red) and lysosomal dye (green) in NRVMs showing mitophagy in NRVMs with USP18 siRNA transfection ( e ) or Ad-USP18 infection ( f ) and the quantitative mitophagy index in each group ( n= 5). Scale bar=9 μm. Protein levels of PINK1, Parkin, Ub, P62, and LC3II in mitochondria from NRVMs transfected with USP18 siRNA ( g ) or infected with Ad-USP18 ( h ). ⁎⁎ P <0.01, ⁎⁎⁎ P <0.001 ⁎⁎⁎⁎ P <0.0001. USP18. Ubiquitin-specific protease 18; I/R. Ischemia/reperfusion; WT. Wild-type; KO. Knockout; P62. Sequestosome 1; LC3. Microtubule-associated protein 1 light chain 3; VDAC. Voltage-dependent anion channel.

    Article Snippet: To block mitophagy, the selective dynamin-related protein 1 (Drp1) inhibitor Mdivi-1 was used (50 μmol/L, MedChemExpress, USA).

    Techniques: Inhibition, Electron Microscopy, Transfection, Infection, Ubiquitin Proteomics, Knock-Out

    A , gene expression of fission and fusion markers Fis1, Drp1, OPA1 and MFN2 in FXN‐cKO and FXNKD hearts normalized to controls. B , western blot images of the corresponding proteins involved in mitochondrial fission–fusion processes. C , protein expression of fission and fusion markers Fis1, Drp1, OPA1 and MFN2 in FXN‐cKO and FXNKD mice normalized to controls. D , protein expression of OPA1‐l/OPA1‐s ratio in FXN‐cKO hearts. E , OPA1‐l/OPA1‐s ratio in FXNKD hearts. F , schematic representation of fusion and fission. N = 8 mouse hearts per genotype for gene expression and n = 4 mouse hearts per genotype for protein expression. Numbers above the brackets indicate the exact P ‐value.

    Journal: The Journal of Physiology

    Article Title: Mitochondrial dynamics and repair differences in two mouse models of Friedreich's ataxia

    doi: 10.1113/JP291356

    Figure Lengend Snippet: A , gene expression of fission and fusion markers Fis1, Drp1, OPA1 and MFN2 in FXN‐cKO and FXNKD hearts normalized to controls. B , western blot images of the corresponding proteins involved in mitochondrial fission–fusion processes. C , protein expression of fission and fusion markers Fis1, Drp1, OPA1 and MFN2 in FXN‐cKO and FXNKD mice normalized to controls. D , protein expression of OPA1‐l/OPA1‐s ratio in FXN‐cKO hearts. E , OPA1‐l/OPA1‐s ratio in FXNKD hearts. F , schematic representation of fusion and fission. N = 8 mouse hearts per genotype for gene expression and n = 4 mouse hearts per genotype for protein expression. Numbers above the brackets indicate the exact P ‐value.

    Article Snippet: Primary antibodies: TFAM (Cell Signalling Technology, 8076), DRP1 (Cell Signalling Technology, 8570), FIS1 (Cell Signalling Technology, 32525), MFN2 (Abcam, ab56889), OPA1 (Cell Signalling Technology, 8047), Pink1 (Abcam, 23707), Parkin (Cell Signalling Technology, 32833), p62 (Abcam, ab56416), FUNDC1 (Cell Signalling Technology, 49240), BNIP3L (Cell Signalling Technology, 12396), LC3 (Cell Signalling Technology, 12 741), ATG7 (Cell Signalling Technology, 8558), ATG12–5 (Cell Signalling Technology, 4180), LAMP1 (Abcam, 24170), CD63 (Cell Signalling Technology, 10112), Cathepsin D (Cell Signalling, 74089), GAPDH (Abcam, ab8245), αTubulin (Millipore Sigma, T6199).

    Techniques: Gene Expression, Western Blot, Expressing